Creatinine Clearance Calculator
Calculate creatinine clearance (CrCl) with the Cockcroft-Gault equation โ widely used for renal drug dosing. Educational tool only.
Cockcroft-Gault was derived from the original creatinine clearance measurements and remains the equation many drug labels were written against, so it is still quoted for renal dosing. In practice, estimates diverge: the equation uses actual body weight, which overestimates clearance in people with obesity and underestimates it in frail or very muscular people. Follow local guidance for any dosing decision.
Frequently asked questions
What is creatinine clearance?
Creatinine clearance estimates how much blood the kidneys clear of creatinine per minute. It is widely used to guide dosing of medicines that are removed by the kidneys.
What is a normal creatinine clearance?
In healthy young adults it is typically in the region of 90 to 140 mL/min, falling gradually with age. Values significantly below the normal range indicate reduced kidney function.
Why use Cockcroft-Gault instead of eGFR?
Many drug labels were written using Cockcroft-Gault, so it remains the required equation for a lot of renal dosing decisions even though eGFR is generally preferred for staging kidney disease.
Related calculators
eGFR Calculator
Estimate glomerular filtration rate (eGFR) with the CKD-EPI 2021 equation, with the CKD stage for the result. Educational tool only.
Anion Gap Calculator
Calculate the anion gap and the albumin-corrected anion gap from sodium, chloride, bicarbonate and albumin. Educational tool only.
Infusion Rate Calculator
Work out infusion rate in mL/hour and drops per minute from volume and time โ the standard IV drip rate calculation. Educational tool only.
Maintenance Fluids Calculator
Calculate maintenance IV fluid requirements using the Holliday-Segar 4-2-1 rule, for adults and children by weight. Educational tool only.